Table 1. Parameters from all the evaluated experiments.
Clinical signs score |
Groups |
Conjuntival redness |
p |
Conjuntival edema |
p |
Lid redness |
p |
Lid Edema |
p |
Mucus secretion |
p |
Vehicle |
2.53±0.20 |
|
2.10±0.19 |
|
0.76±0.07 |
|
0.16±0.05 |
|
2.11±0.18 |
|
Azithromycin |
1.88±0.19 |
<0.05 |
1.48±0.14 |
<0.05 |
0.40±0.07 |
<0.01 |
0.00±0.00 |
<0.05 |
1.43±0.19 |
<0.05 |
RNA expression |
Groups |
COX-2 (RQ) |
p |
IL-6 (RQ) |
p |
MMP-2 (RQ) |
p |
MMP-9 (RQ) |
p |
TNF-α (RQ) |
p |
Vehicle |
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
Azithromycin |
1.745 |
ns |
1.038 |
ns |
0.433 |
0.061 |
0.605 |
ns |
0.828 |
ns |
Protein analysis, macrophage infiltration and mucopolysacharide measurement |
Groups |
IL-6 (ng/µl) |
p |
NF-κβ (%) |
p |
MMP-2 activity (%) |
p |
PAS staining (pixels) |
p |
CD 68 (cell number) |
p |
Vehicle |
2.03±0.45 |
|
100±3.4 |
|
100±6.2 |
|
429926±105314 |
|
134.5±29.6 |
|
Azithromycin |
0.70±0.10 |
<0.05 |
84.18±3.3 |
<0.01 |
80.7±3.9 |
<0.05 |
154685±38542 |
<0.05 |
27.8±9.9 |
<0.05 |