Figure 4. Mapracorat inhibits interleukin-13 plus tumor necrosis factor-α-induced cytokines and intercellular adhesion molecule 1 in human conjunctival fibroblasts. Cells were treated with interleukin-13 (IL-13) plus tumor necrosis factor-α (TNF-α) in the presence of mapracorat or dexamethasone for 48 h. Cytokine and intercellular adhesion molecule 1 (ICAM-1) levels in the media were analyzed with Luminex. Gray bar represents control; black bar represents IL-13 plus TNF-α; black circles plus line represent dexamethasone; white circles plus line represent mapracorat. Lines are the result of a reparameterized four-parameter logistic equation fit to the data. Data are presented as mean ± standard error of the mean (SEM), n=3. * versus IL-13 plus TNF-α; p<0.05.