Table 2 of
Pasquale, Mol Vis 2013; 19:1471-1481. Table 2 of
Pasquale, Mol Vis 2013; 19:1471-1481.
Table 2. Gene significance within the estrogen pathway among women, subdivided by intraocular pressure at the time of glaucoma diagnosis.
| Gene | Chr | # of simple features | # of complex features | Gene p-value1, POAG overall | Gene p-value1, HPG | Gene p-value1, NPG |
|---|---|---|---|---|---|---|
| HSD11B1 | 1 | 6 | 7 | >0.99 | >0.99 | 0.31 |
| HSD3B1 | 1 | 2 | 3 | >0.99 | >0.99 | 0.07 |
| CYP1B1 | 2 | 1 | 7 | 0.29 | >0.99 | >0.99 |
| SULT1E1 | 4 | 2 | 2 | >0.99 | >0.99 | 0.07 |
| UGT2B11 | 4 | 2 | 1 | >0.99 | >0.99 | >0.99 |
| SRD5A1 | 5 | 12 | 6 | 0.06 | 0.49 | 0.45 |
| ESR1 | 6 | 22 | 20 | < 0.001 | < 0.001 | 0.39 |
| AKR1D1 | 7 | 10 | 7 | 0.05 | >0.99 | 0.046 |
| CYP3A4 | 7 | 4 | 2 | 0.01 | < 0.001 | >0.99 |
| CYP11B1 | 8 | 1 | 2 | >0.99 | 0.07 | >0.99 |
| HSD17B3 | 9 | 4 | 8 | >0.99 | >0.99 | 0.50 |
| AKR1C4 | 10 | 2 | 7 | >0.99 | 0.002 | >0.99 |
| CYP17A1 | 10 | 0 | 5 | >0.99 | >0.99 | 0.04 |
| ESR2 | 14 | 2 | 7 | 0.11 | 0.10 | < 0.001 |
| CYP11A1 | 15 | 10 | 4 | 0.35 | >0.99 | 0.34 |
| CYP19A1 | 15 | 15 | 11 | 0.44 | 0.09 | 0.72 |
| CYP1A1 | 15 | 1 | 2 | >0.99 | >0.99 | < 0.001 |
| CYP1A2 | 15 | 2 | 3 | >0.99 | 0.21 | 0.004 |
| HSD17B1 | 17 | 0 | 2 | 0.06 | < 0.001 | >0.99 |
| SULT2B1 | 19 | 10 | 4 | >0.99 | 0.07 | >0.99 |
| COMT | 22 | 11 | 11 | < 0.001 | < 0.001 | 0.01 |
| ARSD | X | 4 | 0 | >0.99 | >0.99 | >0.99 |
| STS | X | 0 | 1 | < 0.001 | < 0.001 | < 0.001 |