Table 1 of Pasquale, Mol Vis 2013; 19:1471-1481.

Table 1. Significance of the estrogen pathway in relation to primary open-angle glaucoma (POAG) in the combined GLAUGEN and NEIGHBOR dataset for overall POAG, and subtypes of POAG defined by intraocular pressure at diagnosis, overall and by gender.

N Mean age (years) Estrogen pathway
p-value
Cases Controls Cases Controls
Overall 3108 3430 65.7 67.7 0.72
Males only 1426 1493 65.6 68.4 >0.99
Females only 1682 1937 65.7 67.3 0.006
HPG 1637 3430 61.8 67.7 0.12
NPG 717 3430 65.5 67.7 0.06
HPG, females only 859 1937 61.8 67.3 <0.001
NPG, females only 419 1937 65.1 67.3 0.09
HPG, males only 778 1493 61.8 68.4 0.92
NPG, males only 298 1493 66.1 68.4 0.59

P-values are permuted p-values. P-values <0.05 are in highlighted in bold. Abbreviations: GLAUGEN=the Glaucoma Genes and Environment study; NEIGHBOR =National Eye Institute Glaucoma Human Genetics Collaboration; HPG=High pressure glaucoma; NPG=Normal pressure glaucoma. NB: The number of HPG and NPG do not add up to 3108 because for some POAG patients the IOP at diagnosis was not known.

Pasquale, Mol Vis 2013; 19:1471-1481. http://www.molvis.org/molvis/v19/1471

©2013 Molecular Vision http://www.molvis.org/molvis/

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