Figure 6. Effects of semaphorin 3A on an oxygen-induced retinopathy model. A: Results of statistical analysis; B: normal control retina; C: oxygen-induced retinopathy (OIR) mouse retina; D: immunoglobulin G (IgG)-treated OIR mouse retina; E: semaphorin 3A Sema3A (100 ng/ml)-treated retina; F: Sema3A (250 ng/ml)-treated retina; G: enlarged image (10×) of the top-right part of panel B; H: enlarged image (10×) of the top-right part of panel E. The ratio of the nonperfusion areas (NPAs) is determined by the NPA (the central dark area) as compared to the whole retina *100%, and the y-axis represents the ratios of different groups comparing to OIR untreated group. ***p<0.001.