Table 4 of Sharif, Mol Vis 2013; 19:1356-1370.
Cynomolgus monkey studies | Monkey IOP changes after topical ocular dosing | ||
---|---|---|---|
Time post- administration (hours) | IOP (mmHg) | IOP change (% of control) | |
Normal pressure monkey eyes | 0 h | 27.1±1.0 | 0 |
BK (100 µg) group | 1 h | 27.1±1.1 | 0.2±2.5% |
BK (100 µg) group | 3 h | 26.6±0.7 | −1.0±2.9% |
BK (100 µg) group | 6 h | 27.2±1.1 | 0.8±2.3% |
BK (100 µg) group | 24 h | 27.8±1.4 | 2.4±3.3% |
Ocular hypertensive monkey eyes | 0 h | 36.8±1.6 | 0 |
BK (100 µg) group | 1 h | 35.9±1.8 | −2.6±1.5% |
BK (100 µg) group | 3 h | 35.7±1.6 | −2.7±3.3% |
BK (100 µg) group | 6 h | 36.6±1.7 | −0.4±3.0% |
BK (100 µg) group | 24 h | 35.3±1.6 | −4.1±2.3% |
Cabergoline (50 µg) group* | 0 h | 34.7±3.0 | 0 |
1 h | nd | -16.0% | |
3 h | nd | -30.4% | |
7 h | nd | -28.8% | |
24 h | nd | -27.3% |