Table 4 of Sharif, Mol Vis 2013; 19:1356-1370.


Table 4. Effects of topical ocular bradykinin on IOP of Cynomolgus monkey eyes

Cynomolgus monkey
studies Monkey IOP changes after topical ocular dosing
Time post- administration (hours) IOP (mmHg) IOP change
(% of control)
Normal pressure monkey eyes 0 h 27.1±1.0 0
BK (100 µg) group 1 h 27.1±1.1 0.2±2.5%
BK (100 µg) group 3 h 26.6±0.7 −1.0±2.9%
BK (100 µg) group 6 h 27.2±1.1 0.8±2.3%
BK (100 µg) group 24 h 27.8±1.4 2.4±3.3%
Ocular hypertensive monkey eyes 0 h 36.8±1.6 0
BK (100 µg) group 1 h 35.9±1.8 −2.6±1.5%
BK (100 µg) group 3 h 35.7±1.6 −2.7±3.3%
BK (100 µg) group 6 h 36.6±1.7 −0.4±3.0%
BK (100 µg) group 24 h 35.3±1.6 −4.1±2.3%
Cabergoline(50 µg) group* 0 h 34.7±3.0 0
1 h nd -16.0%
3 h nd -30.4%
7 h nd -28.8%
24 h nd -27.3%