Table 3 of
Sharif, Mol Vis 2013; 19:1356-1370. Table 3 of
Sharif, Mol Vis 2013; 19:1356-1370.
Table 3. PGE2, PGF2α and PGD2 release induced by various agents in h-CM and CHO-B2 cells
| Compound | PGE2 production in h-CM cells (EC50, nM) | PGF2α production in h-CM cells (EC50, nM) |
|---|---|---|
| BK | 8.9±0.2 | 15.9±9.2 |
| Hyp3-BK | 10.1±4.2 | 9.2±5.3 |
| Lys-BK | 10.3±5.9 | 35.6±16.1 |
| Met-Lys-BK | 32.2±9.0 | 35.6±16.1 |
| RMP-7 | 27.2±9.8 | 18.4±5.2 |
| Des-Arg9-BK | >1,000 | >1,000 |
| HOE-140 | >10,000 | >10,000 |
| (R)-WIN-64338 | >10,000 | >10,000 |
| (S)-WIN-64338 | >10,000 | >10,000 |
| Compound | PGE2 production in CHO-B2 cells (EC50, pM) | PGF2α production in CHO-B2 cells (EC50, pM) | PGD2 production in CHO-B2 cells (EC50, pM) |
|---|---|---|---|
| BK | 32.8±9.03 | 32.1±12.2 | 11.3; 181 |
| RMP-7 | 29.4±16.2 | 26.5±12.8 | nd |
| Hyp3-BK | 30.7±18.5 | 59.3±37.3 | 30.4; 58.2 |
| Lys-BK | 67.5±27.5 | 71.2±25.1 | 26.3; 64.6 |
| Met-Lys-BK | 139.0±51.3 | 106.0±70.5 | 78.8; 96.6 |
| Des-Arg9-BK | >100,000 | >100,000 | >100,000 |
| HOE-140 | >10,000 | >10,000 | nd |
| (R)-WIN-64338 | >10,000 | >10,000 | nd |
| (S)-WIN-64338 | >10,000 | >10,000 | nd |