Molecular Vision: Versura, Mol Vis 2013; 19:1247-1257. Table 8

Table 8. Clinical tests and tear proteins were combined as a test for early DE diagnosis.

Combination n.	Criteria for classifying DE variable (cut off point)	Specificity	Sensitivity	LR+	PPV
1	TFBUT ≤10 s OR Schirmer test I ≤10 mm / 5′	60.0	84.0	2.11	88.0
2	TFBUT ≤10 s OR Cornea NEI score >0	90.0	93.0	13.4	96.1
3	TRANSF ≤0.3 mg/ml OR TP ≤6.5 mg / ml OR LIPOC-1 ≤1.1 mg / ml	96.0	98.0	20.9	99.0
4	ALB >10%versus total TP OR TP ≤6.5 mg / ml OR LIPOC-1 ≤1.1 mg / ml	98.0	91.0	41.8	99.9

The table summarizes the combinations with the best diagnostic performance. The combination of TFBUT, Schirmer Test I, corneal vital staining NEI score exhibited high PPV values (combination #1 and #2). The association TRANSF - TP - LIPOC-1 (combination #3) showed the highest values of specificity and sensitivity, while the association ALB - TP - LIPOC-1 (combination #4) reached a PPV 99.9 value and a 20 fold LR+ value as compared to association of clinical tests.