Table 4 of
Huang, Mol Vis 2013; 19:1211-1221. Table 4 of
Huang, Mol Vis 2013; 19:1211-1221.
Table 4. Results of meta-analysis of the association between rs833061 polymorphism of VEGF-A gene and AMD risk.
| Genotype contrast | Na | Cases/ Controls | OR (95% CI) | Significance (Z test)b | Heterogeneity (Q test) | |||
|---|---|---|---|---|---|---|---|---|
| Z | P | Q | I2 (%) | P | ||||
| overall | 4 | 1180/611 | ||||||
| C versus T | 1.72 (1.00–2.96) | 1.99 | 0.04 | 36.44 | 91.8 | 0 | ||
| CC versus TT | 1.77 (1.00–3.11) | 1.98 | 0.04 | 6.12 | 51 | 0.1 | ||
| TC versus TT | 1.42 (0.75–2.69) | 1.08 | 0.27 | 23.53 | 87.3 | 0 | ||
| CC versus TC | 1.21 (0.87–1.69) | 1.15 | 0.24 | 2.77 | 0 | 0.42 | ||
| (TC+CC) versus TT | 1.49 (0.83–2.68) | 1.35 | 0.17 | 21.72 | 86.2 | 0 | ||
| CC versus (TT+TC) | 1.30 (0.94–1.78) | 1.63 | 0.1 | 2.24 | 0 | 0.52 | ||
| (TT+CC) versus TC | 0.78 (0.45–1.34) | 0.89 | 0.37 | 20.23 | 85.2 | 0 | ||
| dry AMD | 3 | 292/471 | ||||||
| C versus T | 1.99 (0.94–4.18) | 1.82 | 0.06 | 24.88 | 92 | 0 | ||
| CC versus TT | 1.68 (0.99–2.84) | 1.93 | 0.05 | 3.47 | 42.3 | 0.17 | ||
| TC versus TT | 1.67 (0.63–4.43) | 1.03 | 0.3 | 15.73 | 87.3 | 0 | ||
| CC versus TC | 1.25 (0.78–2.01) | 0.93 | 0.35 | 2.49 | 19.7 | 0.28 | ||
| (TC+CC) versus TT | 1.75 (0.73–4.19) | 1.26 | 0.2 | 13.73 | 85.4 | 0 | ||
| CC versus (TT+TC) | 1.37 (0.87–2.15) | 1.38 | 0.16 | 1.27 | 0 | 0.53 | ||
| (TT+CC) versus TC | 0.69 (0.29–1.63) | 0.84 | 0.39 | 15.65 | 87.2 | 0 | ||
| wet AMD | 4 | 758/611 | ||||||
| C versus T | 1.54 (1.03–2.31) | 2.13 | 0.03 | 15.43 | 80.6 | 0 | ||
| CC versus TT | 1.44 (0.98–2.10) | 1.88 | 0.06 | 5.73 | 47.7 | 0.12 | ||
| TC versus TT | 1.34 (0.73–2.45) | 0.97 | 0.33 | 17.21 | 82.6 | 0 | ||
| CC versus TC | 1.14 (0.79–1.63) | 0.73 | 0.46 | 1.99 | 0 | 0.57 | ||
| (TC+CC) versus TT | 1.39 (0.79–2.45) | 1.15 | 0.25 | 16.77 | 82.1 | 0 | ||
| CC versus (TT+TC) | 1.22 (0.87–1.71) | 1.18 | 0.23 | 2.21 | 0 | 0.53 | ||
| (TT+CC) versus TC | 0.80 (0.48–1.33) | 0.84 | 0.4 | 20.23 | 78.7 | 0 | ||