Figure 1 of Choudhuri, Mol Vis 2013; 19:100-113.


Figure 1. Serum and vitreous advanced glycation end-product levels among the different study groups. A: The box-and-whisker plot represents the median and minimum to maximum range of serum advanced glycation end-product (AGE) levels (µg/ml) among the different study groups. The serum AGE level was significantly elevated in subjects with proliferative diabetic retinopathy (PDR; p<0.0001) and nonproliferative diabetic retinopathy (NPDR; p=0.0297) compared to diabetes without retinopathy (DNR) subjects. Further, PDR subjects showed a higher level of serum AGEs than the NPDR group, but the difference was not statistically significant (p=0.2643). The level was found strikingly lower among healthy control (HC) subjects than those considered DNR (p<0.0001). Serum level of AGEs was measured in 105 subjects with PDR, 70 subjects with NPDR, 102 subjects with DNR and from 95 subjects considered as HC. B: The box-and-whisker plot represents the median and minimum to maximum range of vitreous AGE levels (µg/ml) among both the study groups. The vitreous level of AGEs was found to be significantly high among PDR subjects compared to the control group (p<0.0001). In this study, vitreous AGEs was measured among 45 subjects with PDR and 32 subjects considered as control.