Figure 4. Hyperglycemia induces connective tissue growth factor (CTGF) expression in Müller cells. A representative photomicrograph illustrates retinas processed for visualization of CTGF. The CTGF level is low in the retinas of the control rats (A) and increased in the retinas of the diabetic rats after 12 weeks of hyperglycemia (B). Insulin therapy for 12 weeks decreased the staining intensity of CTGF (C). All images were captured at the same magnification. V=vitreous side of the retina. Bar=30 um. n=3/group.