Molecular Vision: Wang, Mol Vis 2012; 18:779-785. Table 2

Table 2. Genotype and allele frequencies of TNF-α (−863).

TNF-α(-863) polymorphism	POAG (%; n=234)	Control (%; n=230)	Odds ratio (95% CI)	p-value
Genotype
C/C	148 (63%)	120 (52%)	1	NA
C/A	70 (30%)	84 (37%)	0.68 (0.45, 1.01)	0.067
A/A	16 (7%)	26 (11%)	0.5 (0.26, 0.98)	0.037
Allele
C	366 (78%)	324 (70%)
A	102 (22%)	136 (30%)	0.66 (0.49, 0.89)	0.007
A allele carriage
AA+CA	86 (37%)	110 (48%)	0.63 (0.44, 0.92)	0.017
CC	148 (63%)	120 (52%)

Distribution of genotypes and allelic frequencies in primary open angle glaucoma (POAG) and controls. In POAG patients, the genotype TNF-α (−863)A/A was less frequent than in controls (7% versus 11%; p=0.037). The frequency of the TNF-α (−863)A allele was significantly decreased in POAG group (22% versus 30%, p=0.007).There were significantly lower carriers of the TNF-α (−863)A allele among patients with POAG than among controls (37% versus 48%; p=0.017), the odds ratio was 0.63 (95% CI: 0.44–0.92).