Table 6 of Chen, Mol Vis 2012; 18:765-778.

Table 6. Two-locus interaction analysis in association with axial ocular dimensions.

    STM NAI Meta-analysis
Gene 1 Gene 2 β SEM p β SEM p β SEM p Adjusted p
Axial length
GJD2 IGF1 −0.097 0.170 0.570 0.224 0.098 0.022 0.144 0.085 0.090 0.246  
GJD2 HGF −0.243 0.171 0.157 −0.318 0.105 0.003 −0.298 0.090 0.001 0.003 *
IGF1 HGF −0.111 0.167 0.505 −0.124 0.093 0.186 −0.121 0.081 0.137 0.357  
Central corneal thickness
GJD2 IGF1 8.596 4.725 0.070 −5.621 3.009 0.062 −1.519 2.538 0.550 0.909  
GJD2 HGF 4.668 4.888 0.340 0.624 3.218 0.846 1.847 2.688 0.492 0.869  
IGF1 HGF −0.160 4.857 0.974 5.192 2.833 0.068 3.833 2.447 0.117 0.312  
Anterior chamber depth
GJD2 IGF1 0.012 0.041 0.776 −0.029 0.030 0.334 −0.015 0.024 0.544 0.905  
GJD2 HGF −0.009 0.042 0.824 −0.032 0.033 0.329 −0.023 0.026 0.371 0.751  
IGF1 HGF −0.093 0.041 0.024 −0.018 0.029 0.533 −0.043 0.024 0.069 0.194  
Lens thickness
GJD2 IGF1 0.033 0.057 0.559 0.002 0.039 0.955 0.012 0.032 0.712 0.976  
GJD2 HGF −0.043 0.059 0.458 −0.046 0.042 0.276 −0.045 0.034 0.189 0.466  
IGF1 HGF 0.097 0.058 0.093 0.014 0.037 0.694 0.038 0.031 0.223 0.531  
Vitreous chamber depth
GJD2 IGF1 −0.144 0.159 0.366 0.260 0.098 0.008 0.149 0.083 0.075 0.207  
GJD2 HGF −0.170 0.161 0.292 −0.246 0.105 0.020 −0.223 0.088 0.011 0.033 **
IGF1 HGF −0.091 0.158 0.566 −0.127 0.093 0.175 −0.118 0.080 0.142 0.368  

*After the interaction item included in the logistic regression, β±SEM were 0.231±0.096 (adjusted p=0.049) and 0.373±0.104 (adjusted p=0.001) for GJD2rs634990 and HGFrs3735520, respectively. **After the interaction item included in the logistic regression, β±SEM were 0.165±0.095 (adjusted p=0.231) and 0.359±0.103 (adjusted p=0.001) for GJD2rs634990 and HGFrs3735520, respectively.

Chen, Mol Vis 2012; 18:765-778. http://www.molvis.org/molvis/v18/a82

©2012 Molecular Vision http://www.molvis.org/molvis/

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