Figure 5. Simplified TGF-β pathway.
Several genes in this pathway are included in our analysis (TGFβ
1/2, BAMBI, ATF3, ID1), as well as
associated genes that were not analyzed (TGF-β RI/II, SMAD3).
TGF-β1 or 2 binds to the TGF-β RI and RII receptor complex, and
results in signal transduction. However, if the TGFβ ligand
binds to a BAMBI/TGF-β RI complex, this signal is not
transduced. TGF-β signaling can lead to the binding of SMAD3
with ATF3. This complex can go on to repress the transcription
of ID1. Independently of the TGF-β pathway, DDIT3
protein can inhibit the transcription of ATF3, while
ATF3 can also suppress the transcription of DDIT3
(insert).