Figure 3. Light damage is more severe in the dorsal retina. Hematoxylin and eosin–stained sagittal cross section of a left eye processed 14 days ALE. The superior rectus muscle (black arrow) and the optic nerve (gray arrow) are observed. The ellipse shows the region most affected by phototoxicity, situated in the dorsal retina at approximately 400 microns from the optic disc. The insert shows a higher magnification of this region, in which the thickness of the outer segments of the photoreceptor layer (white arrow) and the outer nuclear layer (ONL; asterisk) are very much reduced. D: dorsal, V: ventral.