**Figure 4. **Meta-analysis of

rs841853 for its association with all AMD cases (

**A**), early (

**B**), GA (

**C**), CNV (

**D**), mixed (

**E**), CNV + mixed (

**F**), and late AMD (

**G**) cases in six independent study populations. AMD=age-related macular degeneration; GA=geographic atrophy; CNV=choroidal neovascularization;
Mixed cases (combination of GA + CNV). Odds ratios (ORs, squares) and 95% confidence intervals (CI; horizontal lines) are
presented for each study. Also shown is the black diamond of the summary OR using either the additive Mantel-Haenszel fixed
effects model when heterogeneity was absent (

*I*^{2} <25%) or the additive DerSimonian and Laird random effects model when heterogeneity was present (

*I*^{2} >25%). Heterogeneity between studies was tested using Cochran's Q statistic and the I-square statistic for inconsistency.