Figure 3. Prediction of the impact of mutations at the F-helix in the kinase domain of TGFBR2. A: Three-dimensional plot of normal TGFBR2 drawn with Swiss-Pdb Viewer. B: Ramachandran plot of predicted p.V453E. Phi and Psi angles changed after mutation. C and D: The normal and mutant residues at this region. E and F: The structure change after the normal hydrophobic valine residue was replaced the by a hydrophilic glutamic acid.