Figure 7. The results of genetic linkage mapping using bodyweight 96 h after exposure to hyperoxia as the phenotype. A: A genome-wide linkage map of weight on postnatal day 16 after exposure to the oxygen-induced retinopathy model. The threshold of significance was found to be 3.86 (α=0.05), as determined by permutation tests. B: Shows linkage across chromosome 5, with significant linkage at marker CEl-5_93945748 (LOD=3.91, p=0.024). C: Effect plot of genotypes at this marker on postnatal day 16; homozygosity for the BALB/cBJ allelotype at this locus is associated with reduced weight in a recessive manner (ANOVA, p<0.001). The BALB/cByJ allele is designated A^B/c, and the C57BL/6ByJ alleles is designated A^C57.