Figure 5. Model for Zebularine inhibiting PCO. We have shown that Zebularine inhibited MeCP2, and furthermore, inhibits TGFβ-induced α-SMA expression. In this study, we found that Zebularine is capable of inhibiting the crucial cellular events in PCO pathogenesis, including LECs proliferation, attachment, and migration. Therefore, Zebularine could potentially prevent PCO formation. LECs: lens epithelial cells; IOL: intra ocular lens.