Figure 1. Zebularine inhibited LECs proliferation in a dose- and time-dependent manner. The human LECs were treated with various concentrations of Zebularine and the percentage of surviving cells was determined by MTT assay from 12 to 96 h. A time- and dose-dependent decrease in proliferation was seen with the application of Zebularine (10, 50, and 100 μM; p<0.01). A Zebularine concentration of 100 μM accounted for the inhibition of cell proliferation of 57.2% in 96 h.