Figure 5. The effect of the downstream cryptic splice site on a three-dimensional structure of the Rep-1 protein is shown. The mutation cause changes in the last 63 amino acid residues at the C-terminus. The superposition of ribbon structures for wild-type and mutant proteins are shown in light gray and magenta, respectively. In the wild-type protein, the α-helix that might be critical for maintaining global protein stability is included in the orange box and labeled with H.