Figure 1. Algorithm for the study of USH3 in our series. When the family has more than one affected member or there is consanguinity,
we haplotype the family to discard or not discard linkage to CLRN1. In parallel, we send DNA for USH microarray genotyping. If haplotypes are compatible with USH3A linkage or the USH microarray
detects only one mutation, we perform direct sequencing of CLRN1. All the mutations detected with the USH microarray were confirmed with direct sequencing.