Figure 8. Lead-exposed pedicle mitochondria have more cristae with multiple segments than the controls or the lead-exposed spherule
mitochondria. A: The oblique top and (B) side views show only those cristae with multiple segments (18 out of 177 cristae) in a control pedicle mitochondrion. The
outer membrane is shown in blue. C: The oblique top and (D) side views show only cristae with multiple segments (33 out of 68) in a lead-exposed pedicle mitochondrion. Note the much
greater volume of mitochondrion occupied by cristae with multiple segments in the lead example. Examples of typical cristae
with multiple segments in the (E) control and (F) lead mitochondria. G: As is common with the lamellar cristae in the control mitochondria, they are small and do not extend far across the volume.
Lamellar cristae are much rarer in lead-exposed mitochondria, whereas branched cristae with tubular segments are common. H: This is an example with a long tube. I: Branched cristae are equally common in Bcl-xL/Lead mitochondria.