Figure 7. Lead-exposed spherule mitochondria have more cristae with multiple segments than the controls. (A) The top and (B) side views display only cristae with multiple segments (30 out of 204 cristae) in a control spherule mitochondrion. The
outer membrane is shown in blue. C: The top and (D) side views show only cristae with multiple segments (33 out of 98) in a lead-exposed spherule mitochondrion. Note the much
greater volume of mitochondrion occupied by cristae with multiple segments in the lead spherule. Examples of typical lamellar
cristae in (E) control and (F) lead mitochondria. As is common with lamellar cristae in terminal mitochondria, they are small and do not extend far across
the volume. These are examples of typical cristae with multiple segments in (G) control and (H) lead mitochondria. Crista segments are tubes or small lamellae connected by joints (branch points) and are numbered (six
total) in the control crista for illustration. I: A partial remodeling of Bcl-xL/Lead mitochondria produced more thicker, tubular cristae (examples shown) than found in the
control mitochondria.