Figure 6. Tight junction genes and known regulators expressed in the retinal pigment epithelium. Some mRNAs (mRNAs) for transmember
proteins were stably expressed during development, such as F11R, JAM2, CRB3, and occludin. Claudin-1, 2, 3, 5, and 19 presented a trend of downregulation during development, and claudin-4 and 7 presented an upregulation trend during development. JAM-C expression decreased during development. Genes coding for adaptor proteins, such as ZO-1, ZO-2, ZO-3, TJAP1, MPDZ, MAGI1, MAGI3, ACTB, and CTNNA1 (α-catenin), were stably expressed during development. The expression of MAGI2, PARD3, and MLLT4 was significantly downregulated between 13-week-old fetuses and adults. Among the effector proteins analyzed, the expression
of CDK4, cyclin D1, and RAB3B decreased during development.