Figure 3. Visual cycle genes expressed in the retinal pigment epithelium. Some mRNAs (mRNAs) for visual cycle proteins were stably expressed during development, including ABCA4, RBP1, RBP2, RBP5, RLBP1 (CRALBP), CRABP1, and RDH11. Others showed minimal changes between 13- and 16-week-old fetuses, but a significant decrease was observed between 16-week-old fetuses and adults; these included RPE65, LRAT, ALDH1A2, RDH5, and RDH14. IRBP was not detected.