Figure 3. Time-dependent changes in the expression of amyloid procurer protein in retina and optic nerve head after laser photocoagulation treatment in cynomolgus monkeys. Representative photographs of retinal and optic nerve head (ONH) sections immunostained with anti- amyloid procurer protein (APP, green) and counterstained with Hoechst 33,342 (blue) were obtained from the monkeys that had the pressure in their left eye elevated at 9, 11, and 15 weeks. APP immunoreactivity was found to be decreased in retinal and ONH sections of the glaucomatous left eye from 9 weeks onward after intraocular pressure (IOP) elevation. Abbreviations are as follows: GCL represents ganglion cell layer; IPL represents inner plexiform layer; INL represents inner nuclear layer; OPL represents outer plexiform layer; ONL represents outer nuclear layer. Horizontal scale bar indicates 250 µm.