Table 3 of Jiao, Mol Vis 2012; 18:2633-2646.

Table 3. Association of high myopia in the Chaoshan and Guangzhou population groups.

Guangzhou
Region SNP Test Myopia (300 total) Control (308 total) Odds ratio* P**
15q14 rs634990 AA 73 125 1 1.91×10−5
    GA 156 144 1.86 (1.29–2.68) 0.2
    GG 71 39 3.12 (1.92–5.07) 4.25×10−4
    G allele % 0.5 0.36 1.75 (1.39–2.20) 1.57×1−6
    Additive       1.45×10−6
  rs634990 AA 69 125 1 3.31×10−6
    TA 161 143 2.04 (1.41–2.95) 0.07
    TT 70 40 3.17 (1.95–5.16) 9.22×10−4
    T allele % 0.5 0.36 1.78 (1.41–2.23) 8.8×10−7
    Additive       7.01×10−7
15q25 rs8027411 TT 113 108 1 0.5
    GT 146 151 0.92 (0.65–1.31) 0.92
    GG 41 49 0.80 (0.49–1.31) 0.44
    G allele % 0.38 0.4 0.90 (0.72–1.14) 0.39
    Additive       0.38
  rs17175798 CC 112 107 1 0.51
    TC 148 152 0.93 (0.66–1.32) 0.99
    TT 40 49 0.78 (9.48–1.28) 0.37
    T allele % 0.38 0.4 0.90 (0.71–1.30) 0.36
    Additive       0.35
  rs939658 CC 121 116 1 0.5
    TC 139 147 0.93 (0.66–1.32) 0.73
    TT 40 45 0.91 (0.69–1.30) 0.65
    T allele % 0.37 0.39 0.92 (0.73–1.16) 0.36
    Additive       0.48
Chaoshan
Region SNP Genotype Myopia (96 total) Control (96 total) Odds Ratio P**
15q14 rs634990 AA 28 34 1 0.35
    GA 48 46 1.26 (0.67–2.41) 0.77
    GG 20 16 1.51 (0.66–3.47) 0.46
    G allele % 0.46 0.41 1.23 (0.83–1.85) 0.3
    Additive       0.3
  rs524952 AA 28 34 1 0.35
    TA 48 46 1.26 (0.67–2.41) 0.77
    TT 20 16 1.52 (0.66–3.47) 0.46
    T allele % 0.46 0.41 1.24 (0.83–1.35) 0.3
    Additive       0.3
15q25 rs8027411 TT 37 26 1 0.09
    GT 44 54 0.57 (0.30–1.08) 0.15
    GG 14 15 0.66 (0.27–1.59) 0.84
    G allele % 0.38 0.44 0.79 (0.52–1.19) 0.21
    Additive       0.2
  rs17175798 CC 37 27 1 0.13
    TC 44 53 0.61 (0.32–1.15) 0.19
    TT 14 15 0.68 (0.28–1.64) 0.84
    T allele % 0.41 0.38 0.79 (0.52–1.18) 0.25

  Additive       0.24
  rs939658 CC 35 31 1 0.68
    TC 48 50 0.93 (0.66–1.32) 0.77
    TT 13 15 0.91 (0.69–1.30) 0.54
    T allele % 0.37 0.39 0.92 (0.73–1.16) 0.53
    Additive       0.52
Combined
Region SNP Genotype Myopia (396 total) Control (404 total) Odds Ratio* P**
15q14 rs634990 AA 97 159 1 6.63×10−6
    GA 209 189 1.81 (1.32–2.50) 0.09
    GG 90 56 2.63 (1.73–4.00) 0.001
    G allele % 0.49 0.37 1.75 (1.39–2.20) 1.66×10−6
    Additive       1.42×10−6
  rs524952 AA 101 159 1 2.89×10−5
    TA 204 190 1.69 (1.23–2.32) 0.2
    TT 91 55 2.60 (1.72–3.95) 6.10×10−4
    T allele % 0.49 0.37 1.78 (1.41–2.23) 2.72×10−6
    Additive       2.59×10−6
15q25 rs8027411 TT 150 134 1 0.16
    GT 190 205 0.83 (0.61–1.12) 0.43
    GG 55 64 0.77 (0.50–1.18) 0.44
    G allele % 0.38 0.41 0.90 (0.72–1.14) 0.17
    Additive       0.17
  rs17175798 CC 149 134 1 0.38
    TC 192 205 0.84 (0.62–1.14) 0.52
    TT 54 64 0.75 (0.49–1.17) 0.19
    T allale % 0.38 0.41 0.90 (0.71–1.13) 0.17
    Additive       0.16
  rs939658 CC 156 147 1 0.55
    TC 187 197 0.93 (0.66–1.32) 0.66
    TT 53 60 0.83 (0.54–1.28) 0.38
    T allele % 0.37 0.39 0.91 (0.74–1.11) 0.37
    Additive       0.35

* Relative to major allele, or major allele homozygote **p<0.00066 is significant, corresponding to a p<0.-05 after Bonferroni correction for 76 tests.

Jiao, Mol Vis 2012; 18:2633-2646. http://www.molvis.org/molvis/v18/a272

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