Table 1 of Penha, Mol Vis 2012; 18:2608-2622.

Table 1. Summary of experimental plan.

Group number Binocular lens treatment Ipsilateral eye injection (12.5 µl) Contralateral eye injection (12.5 µl) Concentration [µM] ips. eye/contra. eye Time of treatment
Effects of lens wear and intravitreal insulin, MEK- (U0126) and PI3K- (Ly294002)-inhibitor injections on refractive development and axial length
Group 1 Without lenses Saline Insulin 0/0.3 4 days
Group 2 Without lenses U0126 U0126+insulin 50/50+0.3 4 days
Group 3 Without lenses Ly294002 Ly294002+insulin 50/50+0.3 4 days
Group 4 Positive lenses (+7D) Saline Insulin 0/0.3 4 days
Group 5 Positive lenses (+7D) U0126 U0126+insulin 50/50 + 0.3 4 days
Group 6 Positive lenses (+7D) Ly294002 Ly294002+insulin 50/50 + 0.3 4 days
Group 7 Negative lenses (−7D) Saline Insulin 0/0.3 4 days
Group 8 Negative lenses (−7D) U0126 U0126+insulin 50/50+0.3 4 days
Group 9 Negative lenses (−7D) Ly294002 Ly294002+insulin 50/50+0.3 4 days
Effects of intravitreal insulin, MEK- (U0126) and PI3K- (Ly294002) inhibitor injections on phosphorylation levels
Group 10 Without lenses Saline Insulin 0/0.3 2 h
Group 11 Without lenses U0126 Ly294002 100/100 2 h
Group 12 Without lenses U0126 U0126+insulin 50/50+0.3 2 h
Group 13 Without lenses Ly294002 Ly294002+insulin 50/50+0.3 2 h
Group 14 Positive lenses (+7D) Saline Insulin 0/0.3 2 h
Group 15 Positive lenses (+7D) U0126 Ly294002 100/100 2 h
Group 16 Positive lenses (+7D) U0126 U0126+insulin 50/50+0.3 2 h
Group 17 Positive lenses (+7D) Ly294002 Ly294002+insulin 50/50+0.3 2 h
Group 18 Negative lenses (−7D) Saline Insulin 0/0.3 2 h
Group 19 Negative lenses (−7D) U0126 Ly294002 100/100 2 h
Group 20 Negative lenses (−7D) U0126 U0126+insulin 50/50+0.3 2 h
Group 21 Negative lenses (−7D) Ly294002 Ly294002+insulin 50/50+0.3 2 h

Penha, Mol Vis 2012; 18:2608-2622. http://www.molvis.org/molvis/v18/a270

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