Figure 4. Effects of intravitreal saline, insulin, mitogen-activated protein kinase kinase inhibitor U0126, and phosphatidylinositol 3-kinase inhibitor Ly294002 injections on the ocular compartments in chicks treated with negative lenses during four days. The large squares represent the means of the changes±SEM from the beginning of the experiment and four days later. The small squares denote data from individual eyes. Six animals per group were used. Statistically significant differences, as determined with one-way ANOVA, are denoted in the graph (* p<0.05, ** p<0.01).