Figure 2. Effects of intravitreal saline, insulin, mitogen-activated protein kinase kinase inhibitor U0126, and phosphatidylinositol 3-kinase inhibitor Ly294002 injections on the ocular compartments in chicks without any lenses. The large squares represent the means of the changes±SEM from the beginning of the experiment and four days later. The small squares denote data from individual eyes. Six animals per group were used. Animals injected with PI3K inhibitor had deeper vitreous chambers compared with all the other types of injections. No significant changes were observed in anterior chamber depth, lens thickness, and axial length. Statistically significant differences, as determined with one-way ANOVA, are denoted in the graph (* p<0.05, ** p<0.01).