Figure 4. Effect of IMD-0354 on nuclear factor (NK) κB p65 (red) activation in the iris-ciliary body 3 h after lipopolysaccharide injection.
Dual-immunofluorescence labeling showed the NFκB co-localization (yellow) in nuclei (green). Control animals A: were not injected with lipopolysaccharide (LPS); only weak NFκB signal detected in cytoplasm area of the cells, no nuclear
co-localization of NF NFκB was detected. In the group of endotoxin-induced uveitis (EIU) rats treated with IMD-0354 30 mg/kg
B: reductions of NFκB co-localization were observed compared to untreated EIU rats C: Quantitative analysis of NF-κB-positive cells in the iris-ciliary body (ICB) presented in graph D: Data are shown as mean±standard error of mean (n=4). *Significantly different from LPS group (p<0.05).