Figure 1. Histological changes in the iris-ciliary body, vitreous cavity, and retina 24 h after lipopolysaccharide injection. Photographs on the left side show the iris-ciliary body (ICB) region, and those on the right side show the vitreous and retina in rats. Control animals E, J: were not injected with lipopolysaccharide (LPS); no inflammation was observed. Severe inflammatory cell infiltration was observed in endotoxin-induced uveitis (EIU) rats D: I: In the group of EIU rats treated with IMD-0354 (30 mg/kg) A, F: 10 mg/kg; B, G: reductions in cell infiltration were observed compared to untreated EIU rats. No noticeable reduction in cell infiltration was observed in EIU rats treated with IMD-0354 (3 mg/kg) C: H: Infiltrating cells in the ICB of sections K: and in the posterior part of the eye (l) were counted and averaged. Data are shown as mean±standard error of mean (SEM; n=8). *p<0.05, **p<0.01, significantly different from the LPS group.