Table 1 of
Wang, Mol Vis 2012; 18:2578-2585. Table 1 of
Wang, Mol Vis 2012; 18:2578-2585.
Table 1. Summary of SNPs examined and reasons for selecting these candidates.
| Gene | # of SNPs examined | Function | Reasons for selecting gene |
|---|---|---|---|
| PLA2G12A | 1 | Participates in helper T cell Immune response [16] | Association with AMD [33] |
| IL-23R | 11 | Regulates IL-1A expression [35] | Regulator of IL-17 expression [35] |
| STAT3 | 1 | Transcriptional factor in IL-23/IL-17 pathway [35] | Regulator of IL-17 Expression [35] |
| VEGFA | 4 | Promotes Neovascularization [36] | Higher secretion in AMD patients [37] |
| KDR | 1 | Receptor for VEGFA [38] | Differences in receptor expression or function may affect VEGF binding [39] |
| HIF-1A | 3 | Oxygen dependent transcriptional activator [40] | Regulates VEGF expression [40] |