Figure 4. Secretion of vascular endothelial growth factor-C (VEGF-C). Determination of VEGF-C secretion with ELISA (upper panel) and mRNA expression by RT–PCR (lower panel) in ARPE-19 (A, C and HECV B, D cells cultured 24 h in standard conditions (CTR) or in the presence of AGEs (GS) with or without addition of bevacizumab (BE). *p<0.05, **p<0.01 and *** p<0.001 versus CTR; §§§p<0.001 versus GS+BE.*p<0.05, **p<0.01 and *** p<0.001 versus CTR; ^§§§p<0.001 versus GS+BE.