Figure 6. Proliferation of UM cell lines after bevacizumab treatment. Proliferation of UM cell lines was measured by WST-1 assay after exposure to three different doses of bevacizumab during one, three or six days, under normoxic and hypoxic conditions. Cell density is expressed as absorbance (optical density, OD). A dose-dependent decrease of proliferation after treatment with bevacizumab occurs under hypoxic as well as normoxic conditions. AVA1=equivalent human dose: 1.25 mg/ 5.46 ml; AVA10=10 times the equivalent human dose: 12.5 mg/ 5.46 ml; AVA20=20 times the equivalent human dose: 25 mg/ 5.46 ml; CO=control group: culture medium.