Figure 2 of Yang, Mol Vis 2012; 18:2438-2446.

Figure 2. Pedigrees of 11 families with FZD4 or LRP5 mutations. A + sign represents a normal allele, and a - sign indicates a variant. The proband in family QT191 had compound heterozygous mutation, while his mother had a heterozygous c.2484C>G: variant and his father had a heterozygous c.2626G>A variant. The squares brackets around II:1 in family QT476 indicated an adopted proband.