Figure 9. Effect of small interfering RNA on the expression of high mobility group A2 in retinoblastoma (Y79, WERI Rb1) cells in vitro. A: Zymography analysis demonstrates strong activation of MMPs in Y79 cells (lane 4), a mild increase in MMP activation in Y79 cells treated with HMGA2-siRNA (lane 5), strong activation of MMPs in WERI Rb1 cells (lane 2), and a mild decrease in MMP activation in WERI Rb1 cells treated with HMGA2-siRNA (lane 1), protein Molecular Weight ladder (lane 3).