Figure 5. HMGA2 short interfering RNA treatment leads to changes in the gene expression profile in Y79 cells. A: The heat map represents the expression profile of 100 genes differentially modified in response to knockdown of high mobility group A2 (HMGA2) in Y79 cells compared to untreated cells. The horizontal lines represent the relative fold change in the expression of individual genes modified by the HMGA2-short interfering siRNA. Red and green indicate increased and decreased expression, respectively, relative to non-silenced control Y79 cells. B: Functional grouping of upregulated genes and downregulated genes in Y79 cells treated with HMGA2 short interfering siRNA. The functional grouping of all the distinct gene identification for their known biologic function was done according to gene ontology. C: The interlinking of distinct genes identified for their known biologic function are drawn using the GeneMANIA tool.