Molecular Vision: van de Ven, Mol Vis 2012; 18:2271-2278. Table 2

Table 2. Risk allele frequencies in “non CD” AMD, CD and control individuals

			“non CD” AMD/controls			CD/controls		CD/”non CD” AMD
	Controls (%)	“non CD” AMD (%)	p-value	OR (95-C.I.)	CD (%)	p-value	OR (95-C.I.)	p-value	OR (95-C.I.)
rs10490924/ ARMS2 A69S	21.9	42.9	2.0×10⁻²¹	2.94 (2.35–3.67)	38.3	1.7×10⁻⁹	2.25 (1.73–2.93)	0.140	0.83 (0.64–1.06)
rs1061170/ CFH Y402H	38.1	57.7	1.9×10⁻¹⁴	2.17 (1.78–2.65)	64.1	8.6×10⁻¹⁶	2.88 (2.23–3.73)	0.022	1.35 (1.04–1.74)
rs1410996/ CFH	56.9	74.8	9.7×10⁻¹⁵	2.25 (1.83–2.76)	76.8	3.0×10⁻¹¹	2.53 (1.93–3.33)	0.209	1.20 (0.90–1.61)
rs9332739/ C2 E318D	4.7	2.5	0.004	0.47 (0.28–0.79)	1.9	0.016	0.38 (0.17–0.83)	0.744	0.86 (0.34–2.15)
rs2230199/ C3 R102G	20.8	27.4	0.001	1.46 (1.18–1.80)	27.9	0.013	1.42 (1.08–1.88)	0.965	1.01 (0.77–1.32)
rs4151667/ CFB H9L	4.9	2.8	0.006	0.49 (0.29–0.82)	2.3	0.027	0.42 (0.19–0.91)	0.750	0.86 (0.35–2.14)
rs10033900/ CFI	48.2	51.8	0.101	1.17 (0.97–1.42)	51.5	0.232	1.16 (0.91–1.49)	0.809	1.03 (0.79–1.35)
rs7412/ APOE2	8.0	10.7	0.115	1.29 (0.94–1.77)	12.1	0.011	1.65 (1.12–2.42)	0.131	1.37 (0.91–2.05)
rs429358/ APOE4	14.4	10.2	0.058	0.74 (0.54–1.01)	11.1	0.047	0.68 (0.46–1.00)	0.660	0.91 (0.59–1.40)

Abbreviations: AMD=age-related macular degeneration; CD=cuticular drusen; OR=odds ratio; CI=confidence interval; ARMS2=age-related maculopathy susceptibility 2; CFH=complement factor H; C2=complement component 2; C3=complement component 3; CFB=complement factor B; CFI=complement factor I; APOE=apolipoprotein E. Missings in genotypes are <15%. Data are adjusted for age, gender, body-mass index and smoking status. Risk allele frequencies of rs10490924, rs1061170, rs1410996, rs9332739, rs2230199, and rs4151667 are significantly associated with “non CD” AMD compared to controls. Risk allele frequencies of rs10490924, rs1061170, rs1410996, rs9332739, rs2230199, rs4151667, rs7412, and rs429358 are significantly associated with CD compared to controls. The risk allele frequency of rs1061170 is significantly higher in CD compared to “non CD” AMD.