Figure 1. Pedigrees of two Chinese families with primary open-angle glaucoma. Thirteen family members were enrolled in the first family (Family A) and twenty-four members were enrolled in the second family (Family B). The square symbol indicates male; the circle symbol denotes female; the filled symbol represents the affected family member with POAG; and the slashed symbol denotes that the family member is deceased. A phase-known disease haplotype in each family is indicated by a red box. The yellow box is the mutation site.