Figure 7. Binding pose of the best conformation obtained for connexin 46 (Cx46) and connexin 50 (Cx50) domains with acetyl-L-carnitine (ALCAR). A: Cx 46 binding pose. B: Cx 50 binding pose. The proposed binding modes of the drug molecule are shown in a ball and stick model. Hydrogen bonds are shown as dotted green lines, and the bond length between the interacting amino acid residues of the domain and the drug molecule, ALCAR, is indicated. The ARG 133, ARG 136 and TYR 132 residues that interact with ALCAR are also represented.