Figure 2. OHT and POAG family with MYOC Gly326Ser mutation and age of onset. The variant was detected in proband (P, case G62) and an extended analysis was performed in his closer relatives. Sister 01A with POAG, niece 03A has OHT with tendency to angle closure, and first cousin 24A with POAG are heterozygous for Gly326Ser. Cousin 05A has pseudoexfoliative glaucoma. Cousin 08A has been diagnosed with POAG. The three first cousins are heterozygous for MYOC Thr325Thr.