Figure 2. OHT and POAG family with MYOC
Gly326Ser mutation and age of onset. The variant was detected in
proband (P, case G62) and an extended analysis was performed in
his closer relatives. Sister 01A with POAG, niece 03A has OHT
with tendency to angle closure, and first cousin 24A with POAG
are heterozygous for Gly326Ser. Cousin 05A has pseudoexfoliative
glaucoma. Cousin 08A has been diagnosed with POAG. The three
first cousins are heterozygous for MYOC Thr325Thr.