Table 1 of
Paterson, Mol Vis 2012; 18:2043-2052. Table 1 of
Paterson, Mol Vis 2012; 18:2043-2052.
Table 1. Influence of family structure variables on success of SNP genotyping cosegregation for exclusion of potentially causative loci
| Linear regression | |||||||
| Variable | Category | Number of families | Mean (SE) proportion of loci excluded | Parameter estimate (SE) | p-value | ||
| Number of affected individuals analyzed* | 1 | 9 | 0.290 | (0.037) | −0.608 | (0.056) | <0.0001 |
| 2 | 13 | 0.714 | (0.031) | −0.184 | (0.053) | 0.0017 | |
| ≥3 | 7 | 0.898 | (0.042) | 0 | - | - | |
| Number of unaffected individuals analyzed | 0 | 12 | 0.768 | (0.071) | 0 | - | - |
| 1 | 11 | 0.516 | (0.074) | −0.252 | (0.102) | 0.0205 | |
| 2 | 6 | 0.548 | (0.100) | −0.220 | (0.122) | 0.0830 | |
| Analysis of maternal DNA | No | 5 | 0.743 | (0.118) | 0 | - | - |
| Yes | 24 | 0.603 | (0.054) | −0.140 | (0.130) | 0.2897 | |
| Analysis of paternal DNA | No | 8 | 0.772 | (0.089) | 0 | - | - |
| Yes | 21 | 0.571 | (0.055) | −0.201 | (0.105) | 0.0667 | |
| Total number if individuals in sibship | 2 | 4 | 0.384 | (0.117) | −0.409 | (0.158) | 0.0156 |
| 3 | 12 | 0.717 | (0.068) | −0.076 | (0.125) | 0.5510 | |
| 4 | 8 | 0.509 | (0.083) | −0.284 | (0.134) | 0.0441 | |
| ≥5 | 5 | 0.793 | (0.105) | 0 | - | - | |