Figure 1. Cell viability of retinoblastoma cells detected with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The effects of gossypol in different concentrations on human retinoblastoma (Y79) cells (A) and human RPE (ARPE) cells (B) are shown. Cells were cultured at different concentrations of gossypol for 24 h. Gossypol was found to decrease Y79 cell numbers at concentrations of 5, 10, and 20 μM on retinoblastoma cells but had no effect on RPE cells. Time courses of different concentrations of gossypol are shown in (C). Data are presented as mean±SEM. One-way ANOVA with Bonferroni multiple comparisons was used for statistical analysis. n=12–32 in (A), 8–9 in (B), and 6–12 in (C). * p<0.05, compared to the control group.