Figure 1. The haplotype analysis of the family with microsatellite markers from the EDN3 candidate region. The disease haplotype 2–1 is shown by black bars. Note the affected individuals (IV-2 and IV-3) are homozygous for the disease haplotype, whereas both parents III- 1 and III-2 are heterozygous for the disease haplotype and are therefore carriers for the mutation. An arrow marks the index case.