Figure 4. Phenotype of variant lattice corneal dystrophy (L527R mutation) with asymmetric corneal opacity in eye laterality, in a 67-year-old female. A, B: Several bifurcating, thick lattice lines in the superficial stroma of the right cornea. C, D: Discrete and nodular opacities were noted in the deep stroma of the central cornea. E: DNA sequence analysis of the TGFBI gene (upper) and a heterozygous point mutation, CTG→CGG (c.1580 T>G: Leu527Arg in exon 12) in codon 527 (bottom).