Figure 3. Administration of curcumin before ovalbumin (OVA) challenge reduces Th2-type immune responses in an OVA-induced allergic conjunctivitis
model. Splenocytes and monocytes from cervical lymph nodes (CLN) were harvested on day 19 and cultured with 1 mg/mL OVA in
vitro. Culture supernatants were collected at 96 h and cytokine concentration was determined by FACS analysis. Splenocytes
(A) and monocytes from CLN (B) from curcumin-treated mice produced significantly less IL-4 and IL-5 (Th2-type cytokine) compared with those from untreated
mice. * p<0.05, ** p<0.01 (n=6 in each group, three independent experiments). BW, bodyweight.