Figure 1. Selective reduction of IgE antibody secretion in serum of curcumin (Cur)-treated mice. A: Experimental protocol. BALB/c mice were injected intraperitoneally (i.p.) with 1 μg of ovalbumin (OVA) and 200 μl of 1.5% ALUM on days 0 and 7. Curcumin was administered i.p. One h before OVA challenge into conjunctival sac on days 15 and 18. B: Administration of curcumin before OVA challenge led to a profound decrease of Ag-specific IgE antibody secretion in serum. C: Administration of curcumin before OVA challenge did not decrease of Ag-specific IgG antibody secretion in serum. **, p<0.01 (n=6 in each group, three independent experiments).