Figure 5. Comparison of the expression patterns of matrilin-4 in healthy, granular type I, and lattice type I stromal dystrophy corneal buttons. Some immunolabeling was recorded in healthy corneal epithelium (A). In granular dystrophy, all epithelial layers were positive for matrilin-4, and no Bowman’s layer was present under the epithelial basement membrane (B). Altered epithelial cell morphology in the basal layer was observed, with strong basal immunolabeling for matrilin-4 in lattice type I dystrophy (C). Scale bar 100 μm.